Clinical studies are ongoing to evaluate the efficacy of new therapeutic agents for variety of indications. The staff are experienced in topical, systemic and novel biologic therapeutics. They coordinate trials across multiple locations, including the NIH-funded General Clinical Research Center and the Ireland Cancer Center Infusion Unit. The Clinical Trials Unit (CTU) maintains a professional infrastructure for testing new agents and protocols for patients with skin diseases. The dermatology CTU provides a resource for industry and government for skilled assessment of skin disease. The Department has cultivated a very large pool of patients, both from within the institution and from a large referral base, who are regularly recruited into clinical trials, effecting rapid enrollment. The CTU is actively involved in study design, all phases of clinical testing, and the FDA approval process of investigational new drugs.
The Clinical Trials Unit of the Department of Dermatology provides patients with the opportunity to participate in studies of the newest medications that are being evaluated as potential therapies. Past projects include trials in psoriasis, eczema, skin lymphoma, melanoma, shingles, pemphigus, bullous pemphigoid, alopecia, acne, warts, fungal infections, onychomycosis, tinea pedis/cruris/versicolor, herpes zoster, genital warts, postherpic neuralgia, Kaposi's sarcoma, graft vs. host disease, urticaria, and photoaging. All patients seen in our practice are eligible to enroll in such studies which are funded by pharmaceutical, private, or governmental sources.
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An Open-Label, Single Center Study to Assess the Safety and Efficacy of a 12 Week Treatment Course of CC-10004 in Adults with Recalcitrant Prurigo Nodularis
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A Double-blind, Randomized, Two-Dose, Parallel Group, Multicenter Clinical Trial of HuMax-CD4, a Fully Human Monoclonal Anti-CD4 Antibody, in Patients with Mycosis Fungoides type CTCL (stage IB-IVB) who are Refractory or Intolerant to Targretin? (bexarotene) and one other Standard Therapy.
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Relationship between dietary intake and severity of psoriasis
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Epidemiology, comorbidities, risk factors and treatment profile of psoriasis patients
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Evaluation of Cardiovascular Risk Profile in Psoriasis Patients by the Use of Pro-inflammatory Markers in Skin and Cardiovascular Disease
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Disulfiram Treatment in Patients with Psoriasis
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A Phase 2, Single Arm Study to Evaluate the Safety and Pharmacokinetics of Alefacept in Adolescent Subjects with Moderate to Severe Psoriasis
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Impact of the Severity of Pediatric Psoriasis on Childhood Body Mass Index and Comorbid Risk Factors: an epidemiologic analysis
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A Pilot Study of Reiki Therapy for Psoriasis and Psoriasis-related Stress
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Phase IV Randomized Study of Two Dose Levels of Targretin? Capsules in Patients with Refractory Cutaneous Tcell Lymphoma
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Phase I/II Multicenter Clinical Trial of O6Benzylguanine and Topical Carmustine in the Treatment of Refractory Early-Stage (IA-IIA) Cutaneous T-cell Lymphoma
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Genetic Basis of Skin Disease in Twin Pairs and Their Families
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Mechanistically-Based Optimazation of UV Radiation Therapy in Psoriasis Patients (VA)
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Blood and Skin Samples from Persons with Normal Skin, Inflamed Skin, Neoplastic Skin and Skin Exposed to Contact Allergens
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Protection Against Adverse Effects of UV Radiation on Human Skin
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Phase 1 Clinical Trial Using Topical Silicon Phthalocyanine (Pc4) Photodynamic Therapy (PDT) for the Treatment of Pre-malignant and Malignant Skin Conditions
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Phase 1 Trial on Silicon Phthalocyanine Pc4 for Photodynamic Therapy of Psoriasis: Single dose study
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Effect of Etanercept on UV-induced Contact Sensitivity Suppression in Psoriasis Patients
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Clinical Trial on Surrogate Markers for Integrated Protection Factor
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Understanding Mechanisms in Susceptibility to Skin Irritants in Health Care Workers with Irritant Contact Dermatitsis (ICD)
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Determination of Irritatancy and Sensitization Prevalance For Benzalkonium Chloride and Benzethonium Chloride
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Patch Testing in Atropic Dermatitis Patients
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Allergic Contact Dermatitis Genetic Predisposition Study
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Minimizing the Pain of Lidocaine Injection by Controlling the Angle of Needle Insertion
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How Screening and Counseling by Primary Care Providers nd Dermatologists Influenced Prognosis of Melanomas and Non-Melanoma Skin Cancers
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Multicenter Prospective Rare Cutaneous Tumor Database and Tissue Bank
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Epigentic Responses to Solar UVR in Melanocytes
For more information regarding our clinical trials, please call 216-844-7394.
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